Dapsone (Dapsone)100mg – 1000 tablet

Dapsone Information

Pronunciation

DAP sone

What is this drug used for?

• It is used to treat a skin problem called dermatitis herpetiformis.

• It is used to treat leprosy.

• It may be given to you for other reasons. Talk with the doctor.

Frequently reported side effects of this drug

• Nausea

• Vomiting

• Headache

• Abdominal pain

• Trouble sleeping

• Dizziness

Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:

• Infection

• Liver problems dark urine, fatigue, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or yellow skin

• Kidney problems like not able to pass urine, blood in your urine, change in amount of urine passed, or weight gain

• Lupus like rash on the cheeks or other body parts, sunburn easy, muscle or joint pain, chest pain or shortness of breath, or swelling in the arms or legs

• Pancreatitis like severe abdominal pain, severe back pain, severe nausea, or vomiting

• Severe loss of strength and energy

• Burning or numbness feeling

• Muscle weakness

• Difficulty moving

• Blurred vision

• Noise or ringing in the ears

• Mood changes

• Bruising

• Bleeding

• Pale skin

• Fast heartbeat

• Purple spots or redness of skin

• Toxic epidermal necrolysis like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in mouth, throat, nose, or eyes.

• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.

Medication Safety Issues

Sound-alike/look-alike issues:

Storage and Stability

Store at 20°C to 25°C (68°F to 76°F). Protect from light.

Adverse Reactions

Cardiovascular: Tachycardia

Central nervous system: Fever, headache, insomnia, psychosis (oral/topical), vertigo

Dermatologic: Bullous and exfoliative dermatitis, erythema nodosum, exfoliative dermatitis, morbilliform and scarlatiniform reactions, phototoxicity, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria

Endocrine & metabolic: Hypoalbuminemia (without proteinuria), male infertility

Gastrointestinal: Abdominal pain, nausea, pancreatitis, vomiting

Hematologic: Agranulocytosis, anemia, leukopenia, pure red cell aplasia (case report); hemolysis (dose related; seen in patients with and without G6PD deficiency), hemoglobin decrease (1-2 g/dL), reticulocyte increase, methemoglobinemia, red cell life span shortened

Hepatic: Cholestatic jaundice, hepatitis

Neuromuscular & skeletal: Lower motor neuron toxicity (prolonged therapy), lupus-like syndrome, peripheral neuropathy (rare, nonleprosy patients)

Ophthalmic: Blurred vision

Otic: Tinnitus

Renal: Albuminuria, nephrotic syndrome, renal papillary necrosis

Respiratory: Interstitial pneumonitis, pulmonary eosinophilia

Miscellaneous: Infectious mononucleosis-like syndrome (rash, fever, lymphadenopathy, hepatic dysfunction) –