Arip MT (Aripiprazole Discmelt)15mg – 100 tablet

Aripiprazole Information

Pronunciation

ay ri PIP ray zole

What is this drug used for?

• It is used to treat schizophrenia.

• It is used to treat bipolar problems.

• It is used to treat low mood (depression).

• It is used to treat certain behavior problems in patients with autism.

• It is used to treat Tourette’s syndrome.

• It may be given to you for other reasons. Talk with the doctor.

Frequently reported side effects of this drug

• Fatigue

• Agitation

• Anxiety

• Headache

• Nausea

• Vomiting

• Weight gain

• Constipation

• Trouble sleeping

• Change in appetite

• Lack of appetite

• Stuffy nose

• Sore throat

• Dry mouth

• Tremors

• Drooling

Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:

• Infection

• Depression like thoughts of suicide, anxiety, emotional instability, or confusion.

• High blood sugar like confusion, fatigue, increased thirst, increased hunger, passing a lot of urine, flushing, fast breathing, or breath that smells like fruit.

• Abnormal movements

• Twitching

• Change in balance

• Difficulty swallowing

• Vision changes

• Eye pain

• Eye irritation

• Difficulty speaking

• Severe dizziness

• Passing out

• Loss of strength and energy

• Blurred vision

• Uncontrollable urges

• Neuroleptic malignant syndrome like fever, muscle cramps or stiffness, dizziness, severe headache, confusion, change in thinking, fast heartbeat, abnormal heartbeat, or sweating a lot.

• Tardive dyskinesia like unable to control body movements; tongue, face, mouth, or jaw sticking out; mouth puckering; or puffing cheeks.

• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.

Medication Safety Issues

Product Availability

Abilify immediate-release injection (9.75 mg/1.3 mL) has been discontinued in the US for more than 1 year.

Storage and Stability

Injection, powder (extended release):

Prefilled syringe: Store below 30°C (86°F). Do not freeze. Protect from light and store in original package.

Vial for reconstitution: Store unused vials at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). If the suspension is not administered immediately after reconstitution, store at room temperature in the vial (do not store in a syringe).

Oral solution and tablets: Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Use oral solution within 6 months after opening. Do not store in conditions where tablets are exposed to humid conditions.

Mycite Patch: Store at 15°C to 30°C (59°F to 86°F); 15% to 93% relative humidity.

Adverse Reactions

IM:

Cardiovascular: Anxiety, tachycardia

Central nervous system: Akathisia (dose-related), dizziness, drowsiness, dystonia, extrapyramidal reaction, fatigue (dose-related), headache, insomnia, restlessness, sedation

Endocrine & metabolic: Decreased HDL cholesterol, increased LDL cholesterol, increased serum cholesterol, increased serum glucose, increased serum triglycerides, weight gain, weight loss

Gastrointestinal: Constipation, diarrhea, vomiting, xerostomia

Hematologic & oncologic: Neutropenia

Local: Injection site reaction (including erythema, induration, inflammation, hemorrhage, pruritus, rash, swelling), pain at injection site

Neuromuscular & skeletal: Arthralgia, back pain, musculoskeletal pain, myalgia, tremor (dose-related)

Respiratory: Nasal congestion, upper respiratory tract infection

Oral:

Cardiovascular: Orthostatic hypotension

Central nervous system: Agitation, akathisia (dose-related; more common in adults), anxiety, dizziness, drooling (children and adolescents), drowsiness (more common in children and adolescents), dystonia, extrapyramidal reaction (dose-related; more common in children and adolescents), fatigue (dose-related; more common in children and adolescents), headache (more common in adults), insomnia, irritability (children and adolescents), lethargy (older adults and children), pain, restlessness, sedation (dose-related; more common in children and adolescents)

Dermatologic: Skin rash

Endocrine & metabolic: Decreased HDL cholesterol (children and adolescents), increased serum cholesterol, increased serum glucose (more common in adults), increased serum triglycerides, weight gain (more common in children and adolescents), weight loss

Gastrointestinal: Abdominal distress, anorexia, constipation (more common in adults), decreased appetite (children and adolescents), diarrhea (children and adolescents), dyspepsia, increased appetite (children and adolescents), nausea, stomach discomfort, toothache, upper abdominal pain (children and adolescents), vomiting, xerostomia

Genitourinary: Urinary incontinence (older adults)

Local: Application site rash (Mycite patch)

Neuromuscular & skeletal: Arthralgia, asthenia (children and adolescents), limb pain, muscle rigidity (children and adolescents), muscle spasm, myalgia, stiffness, tremor (dose-related)

Ophthalmic: Blurred vision

Respiratory: Cough, epistaxis (children and adolescents), nasopharyngitis (children and adolescents), pharyngolaryngeal pain

Miscellaneous: Fever (children and adolescents)

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