Combigan Eye Drop (Combigan)0.2% 0.5%

Brimonidine and Timolol Information

What is this drug used for?

• It is used to treat glaucoma.
• It is used to lower high eye pressure.

Possible side effects

Brimonidine and Timolol  may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• Eye irritation.
• Itching.
• Burning.
• Stinging.
• Feeling sleepy.

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Change in eyesight, eye pain, or very bad eye irritation.
• Shortness of breath, a big weight gain, or swelling in the arms or legs.
• Slow heartbeat.
• A heartbeat that does not feel normal.
• Chest pain.
• Dizziness or passing out.
• Trouble breathing.
• Muscle weakness.

Medication Safety Issues

Sound-alike/look-alike issues:

Storage and Stability

Store at 15°C to 25°C (59°F to 77°F). Protect from light.

Adverse Reactions

Percentages as reported with combination product. Also see individual agents.

>15%: Central nervous system: Drowsiness (children 25% to 83%)

5% to 15%: Ophthalmic: Allergic conjunctivitis, burning sensation of eyes, conjunctival hyperemia, eye pruritus, follicular conjunctivitis, stinging of eyes

1% to 5%:

Cardiovascular: Hypertension

Central nervous system: Depression, foreign body sensation of eye, headache

Dermatologic: Erythema of eyelid

Gastrointestinal: Xerostomia

Neuromuscular & skeletal: Weakness

Ophthalmic: Blepharitis, blurred vision, corneal erosion, dry eye syndrome, epiphora, eye discharge, eye irritation, eye pain, eyelid edema, eyelid pruritus, superficial punctate keratitis –