Cytomid (Flutamide)250mg – 100 tablet

Flutamide Information

What is this drug used for?

• It is used to treat prostate cancer.
• It may be given to you for other reasons. Talk with the doctor.

Possible side effects

Flutamide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• Hot flashes.
• Upset stomach or throwing up.
• Enlarged breasts.
• Lowered interest in sex.
• Not able to get or keep an erection.
• Diarrhea

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Blood in the urine.
• Bleeding from rectum or rectal pain.
• Feeling very tired or weak.
• Shortness of breath.
• Blue or gray skin color.
• Severe diarrhea.

Medication Safety Issues

Sound-alike/look-alike issues:

Storage and Stability

Adverse Reactions

>10%:

Endocrine & metabolic: Hot flash (46% to 61%), galactorrhea (9% to 42%), decreased libido (36%), increased lactate dehydrogenase (transient; mild)

Gastrointestinal: Diarrhea (12% to 40%), vomiting (11% to 12%)

Genitourinary: Impotence (33%), cystitis (16%), breast tenderness

Hematologic & oncologic: Rectal hemorrhage (14%), tumor flare

Hepatic: Increased serum AST (transient; mild)

1% to 10%:

Cardiovascular: Edema (4%), hypertension (1%)

Central nervous system: Anxiety, confusion, depression, dizziness, drowsiness, headache, insomnia, nervousness

Dermatologic: Skin rash (3% to 8%), ecchymoses, pruritus

Endocrine & metabolic: Gynecomastia (9%)

Gastrointestinal: Nausea (9%), proctitis (8%), gastric distress (4% to 6%), anorexia (4%), constipation, dyspepsia, increased appetite

Genitourinary: Hematuria (7%)

Hematologic & oncologic: Anemia (6%), leukopenia (3%), thrombocytopenia (1%)

Infection: Herpes zoster

Neuromuscular & skeletal: Weakness (1%)

<1%, postmarketing, and case reports: Cholestatic jaundice, hemolytic anemia, hepatic encephalopathy, hepatic failure, hepatic necrosis, hepatitis, hypersensitivity pneumonitis, increased blood urea nitrogen, increased gamma-glutamyl transferase, increased serum ALT, increased serum bilirubin, increased serum creatinine, jaundice, macrocytic anemia, malignant neoplasm of breast (male), methemoglobinemia, myocardial infarction, oligospermia, pulmonary embolism, skin photosensitivity, sulfhemoglobinemia, thrombophlebitis, urine discoloration (amber, yellow-green) –