HYDRAZIDE (Hydrochlorazide (HCTZ))12. 5mg – 100 tablet

Hydrochlorothiazide Information

Pronunciation

hye droe klor oh THYE a zide

What is this drug used for?

• It is used to treat high blood pressure.

• It is used to get rid of extra fluid.

• It may be given to you for other reasons. Talk with the doctor.

Frequently reported side effects of this drug

• Constipation

• Diarrhea

• Dizziness

• Lack of appetite

• Nausea

• Vomiting

• Headache

Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:

• High blood sugar like confusion, fatigue, more thirst, hunger, passing a lot of urine, flushing, fast breathing, or breath that smells like fruit.

• Fluid and electrolyte problems like mood changes, confusion, muscle pain or weakness, abnormal heartbeat, severe dizziness or passing out, fast heartbeat, more thirst, seizures, loss of strength and energy, lack of appetite, unable to pass urine or change in the amount of urine produced, dry mouth, dry eyes, or nausea or vomiting.

• Kidney problems like unable to pass urine, blood in the urine, change in amount of urine passed, or weight gain.

• Pancreatitis like severe abdominal pain, severe back pain, severe nausea, or vomiting.

• Lupus like rash on the cheeks or other body parts, sunburn easy, muscle or joint pain, chest pain or shortness of breath, or swelling in the arms or legs

• Shortness of breath

• Dark urine

• Yellow skin

• Chills

• Sore throat

• Burning or numbness feeling

• Bruising

• Bleeding

• Severe loss of strength and energy

• Skin changes

• Vision changes

• Eye pain

• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.

Medication Safety Issues

Storage and Stability

Store at 20°C to 25°C (68°F to 77°F). Protect from light and moisture.

Adverse Reactions

The occurrence of adverse events are dose related, with the majority occurring with doses ≥25 mg.

Cardiovascular: Hypotension, necrotizing angiitis, orthostatic hypotension

Central nervous system: Dizziness, headache, paresthesia, restlessness, vertigo

Dermatologic: Alopecia, erythema multiforme, exfoliative dermatitis, skin photosensitivity, skin rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria

Endocrine & metabolic: Glycosuria, hypercalcemia, hyperglycemia, hyperuricemia, hypochloremic alkalosis, hypokalemia, hypomagnesemia, hyponatremia

Gastrointestinal: Abdominal cramps, anorexia, constipation, diarrhea, gastric irritation, nausea, pancreatitis, sialadenitis, vomiting

Genitourinary: Impotence

Hematologic & oncologic: Agranulocytosis, aplastic anemia, hemolytic anemia, leukopenia, purpura, thrombocytopenia

Hepatic: Jaundice

Hypersensitivity: Anaphylaxis

Neuromuscular & skeletal: Muscle spasm, weakness

Ophthalmic: Transient blurred vision, xanthopsia

Renal: Interstitial nephritis, renal failure, renal insufficiency

Respiratory: Respiratory distress, pneumonitis, pulmonary edema

Miscellaneous: Fever

Rare but important or life-threatening: Allergic myocarditis, eosinophilic pneumonitis, hepatic insufficiency, malignant neoplasm of lip (Friedman 2012), skin carcinoma (Pedersen 2018), systemic lupus erythematosus –