P-CARZINE (Matulane)50MG – 50 tablet

Procarbazine Information

Pronunciation

(proe KAR ba zeen)

What is this drug used for?

• It is used to treat a type of lymphoma.

• It may be given to you for other reasons. Talk with the doctor.

Frequently reported side effects of this drug

• Fatigue

• Nausea

• Vomiting

• Lack of appetite

• Dry mouth

• Hair loss

• Abdominal pain

• Constipation

• Headache

• Muscle pain

• Joint pain

• Skin discoloration

• Flushing

• Trouble sleeping

Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:

• Infection

• Bleeding like vomiting blood or vomit that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a reason or that get bigger; or any severe or persistent bleeding

• Liver problems like dark urine, fatigue, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or yellow skin

• Shortness of breath

• Severe dizziness

• Passing out

• Fast heartbeat

• Swelling

• Confusion

• Sensitivity to light

• Passing a lot of urine

• Sweating a lot

• Slurred speech

• Enlarged breasts (males)

• Diarrhea

• Burning or numbness feeling

• Vision changes

• Eye pain

• Severe eye irritation

• Nightmares

• Hearing loss

• Tremors

• Seizures

• Change in balance

• Severe loss of strength and energy

• Mouth irritation

• Mouth sores

• Trouble swallowing

• Involuntary eye movements

• Mood changes

• Sensing things that seem real but are not

• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.

Medication Safety Issues

Storage and Stability

Protect from light.

Adverse Reaction

Cardiovascular: Edema, flushing, hypotension, syncope, tachycardia

Central nervous system: Apprehension, ataxia, chills, coma, confusion, depression, dizziness, drowsiness, falling, fatigue, hallucination, headache, hyporeflexia, insomnia, lethargy, nervousness, neuropathy, nightmares, pain, paresthesia, seizure, slurred speech, unsteadiness

Dermatologic: Alopecia, dermatitis, diaphoresis, hyperpigmentation, pruritus, skin rash, urticaria

Endocrine & metabolic: Gynecomastia (in prepubertal and early pubertal males)

Gastrointestinal: Abdominal pain, anorexia, constipation, diarrhea, dysphagia, hematemesis, melena, nausea and vomiting (increasing the dose in a stepwise fashion over several days may minimize), stomatitis, xerostomia

Genitourinary: Azoospermia (reported with combination chemotherapy), hematuria, nocturia, reduced fertility

Hematologic & oncologic: Anemia, bone marrow depression, eosinophilia, hemolysis (in patients with G6PD deficiency), hemolytic anemia, malignant neoplasm (secondary; nonlymphoid; reported with combination therapy), pancytopenia, petechia, purpura, thrombocytopenia

Hepatic: Hepatic insufficiency, jaundice

Hypersensitivity: Hypersensitivity reaction

Infection: Herpes virus infection, increased susceptibility to infection

Neuromuscular & skeletal: Arthralgia, foot-drop, myalgia, tremor, weakness

Ophthalmic: Accommodation disturbance, diplopia, nystagmus, papilledema, photophobia, retinal hemorrhage

Otic: Hearing loss

Renal: Polyuria

Respiratory: Cough, epistaxis, hemoptysis, hoarseness, pleural effusion, pneumonitis, pulmonary toxicity

Miscellaneous: Fever

  –