Progynova 2 mg (Estradiol Valerate)

What is Progynova used for?

Progynova 2 mg are a hormone replacement therapy (HRT) used to substitute for the lack of oestrogen production by the ovaries that happens during menopause or following surgical removal of the ovaries, to relieve moderate to severe symptoms of menopause caused by oestrogen deficiency, such as hot flushes, night sweats, sleeplessness, vaginal dryness, headaches, mood swings, lack of concentration and loss of energy. Progynova is also are also used to help prevent postmenopausal bone loss (osteoporosis) and reduce risk of fracture. Progynova is used to relieve the symptoms of advanced androgen-dependent carcinoma prostate cancer. Oestrogen stimulates the development of female s**ual characteristics, and Progynova is used as part of a transgender hormone therapy for male to female transs**uals.

How does Progynova work?

Progynova 2 mg contain oestradiol valerate, a synthetic form of naturally occurring oestradiol, which is the major and most active form of the female s** hormone oestrogen, and is biologically similar to the natural hormone. Each vial contains 2mg oestradiol valerate in a sterile oil solution, which is a long-acting estrogen preparation for intramuscular use by injection. Oestrogen is a st***d hormone produced by the ovaries that binds to specific receptors inside oestrogen-responsive cells and stimulates them to make proteins involved in producing secondary s**ual characteristics, such as breast development and in regulating the menstrual cycle. Oestrogen also has several other actions in various metabolic processes including maintaining bone mass and lipid (fat) metabolism.

What does Progynova contain?

Progynova 2 mg vials contain the active ingredient oestradiol valerate, a synthetic form of naturally occurring oestradiol, which is the major and most active form of the female s** hormone oestrogen and is responsible for the development of female s**ual characteristics and regulation of the menstrual cycle. Each vial also contains a 2ml vehicle being Peanut oil (Arachis Oil)@Treating symptoms of menopause with Progynova

Progynova 2mg injections contain oestradiol valerate a long-acting estrogen, used to treat symptoms of menopause caused by a lack of endogenous oestrogen (produced by the ovaries), such as hot flushes, night sweats, sleeplessness, vaginal dryness, headaches, mood swings, lack of concentration and loss of energy.

Progynova Dosage and Administration

Progynova (Estradiol Valerate) comes as a liquid to inject into a muscle. Consult you physician or health care professional about frequency and correct dosage for your needs. It is usually injected by a physician. Tell your physician and pharmacist if you are allergic to estrogen injection, any other estrogen products, any other medications, or any of the ingredients in estrogen injection. Ask your pharmacist or check the manufacturer`s patient information for a list of the ingredients in the brand of estrogen injection you plan to use.

Progynova for hormone replacement therapy (HRT)

Progynova 2mg injections contain the active ingredient oestradiol valerate, a synthetic form of naturally occurring oestradiol, which is the major and most active form of the female s** hormone oestrogen and is responsible for the development of female s**ual characteristics and regulation of the menstrual cycle. Progynova 2mg injections are used for hormone replacement therapy (HRT) and substitute for the loss of oestrogen production by the ovaries that occurs during menopause or following surgical removal of the ovaries.

Progynova for transgender treatment

Progynova 2mg injections can be used as part of a gender reassignment program for male to female transs**uals, by providing a source of oestradiol, an active form of the female hormone oestrogen. Progynova 2mg injections stimulate the development of female secondary s**ual characteristics, such as breast development and also induce metabolic changes such as fat distribution to redefine the general body shape.

Progynova for feminising hormone therapy

Progynova 2mg injections contain oestradiol valerate in a sterile oil solution, which is a long-acting estrogen preparation for intramuscular use by injection. Oestradiol valerate is a prodrug (or precursor) of natural human 27β-oestradiol, the most feminising form of the female hormone oestrogen, which provides a very effective means of feminisation when used as part of a gender reassignment program for male to female transs**uals. Progynova stimulates the development of female secondary s**ual characteristics, such as breast development and also induces metabolic changes such as fat distribution to redefine the general body shape, while at the same time Progynova overrides the effects of testosterone. The more direct route of administration provided by injection may speed the physical change by creating a higher and more constant source of oestrogen.

What are the side effects of Progynova?

The most frequently reported side effects when taking Progynova 2mg injections are breast tenderness, breast pain, abdominal pain, nausea, oedema, and headache, skin rash and itching, insomnia and depression. More severe side effects include changes in liver function at higher doses and increased risk of dementia if initiated in women aged 65 or older.

What are the health risks of Progynova?

Long-term HRT with Progynova does have associated health risks, including an increased risk of breast cancer, endometrial cancer, stroke and deep vein thrombosis. For women with an intact uterus adding a progestogen to an oestrogen replacement regimen like Progynova for at least 2 days per cycle is recommended to reduce the risk of endometrial cancer.

When should Progynova not be used?

You should not use Progynova if you:

• • have a past or family history of carcinoma of the breast, endometrial carcinoma or liver disease• have deep venous thrombosis, thromboembolic disorders, cerebral vascular accident associated with oestrogen use• abnormal genital bleeding of unknown cause• are pregnant or planning to become pregnant• are allergic to oestradiol valerate or any of the ingredients in Progynova tablets• are taking other medications that may interact with Progynova, such as anticonvulsants like phenytoin and carbamazepin, barbiturates, anti-infectives like rifampicin, rifabutin, nevirapine, antibiotics like penicillin,

  • A diabetic taking antidiabetics or insulin, without discussion with your doctor, as Progynova may affect your glucose tolerance

How should Progynova be injected?

Use a clean dry needle and syringe and inject the contents of one vial of Progynova (2ml) volume) deep into the upper, outer area of the gluteal muscle. The usual dose is one injection every 4 weeks, depending On what you are being treated for. How long you take Progynova injections should be as recommended by your doctor and may be for several months.

How long should you take Progynova?

You should take Progynova 2mg injections every few weeks or as recommended by your doctor for as long as your doctor recommends.

Missed dose of Progynova

If you miss a dose of Progynova take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose. [?how does this apply for infrequent injection?]

How should Progynova be stored?

Keep Progynova vials in their box until used. Store at room temperature below 25°C, keep away from direct sunlight and do not refrigerate.

Expert advice

• • The drug can cause nausea, vomitting or breast tenderness.• Do not use estradiol patches over breast stop taking estradiol and see a doctor immediately if you notice any of the following when taking estradiol:• yellowing of your skin or the whites of your eyes (jaundice).• rise in your blood pressure (symptoms may be headache, tiredness, dizziness).• new onset migraine-like headaches.• pregnancy.

  • signs of a blood clot, such as: painful swelling and redness of the legs, sudden chest pain, difficulty in breathing.

  • Do not consider estradiol alone as a contraceptive. It must be used with progestogen to provide contraceptive benefits.

  • Consult your doctor if you have unusual vaginal bleeding while taking this drug, Immediately consult your doctor if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision. This medicine should not be taken for a very long period.

  • Consult your doctor from time to time to check if you still need it.

Frequently asked questions

Estradiol

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